Rabbit anti-Alsin Antibody
Catalog #
Alsin
Human
,Mouse
WB
Rabbit
Polyclonal
Whole IgG
Between 1250 and 1300
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human,
Mouse
Human
2 - 8 °C
1 year from date of receipt
Alsin contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. Alsin localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in the gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis [taken from NCBI Entrez Gene (Gene ID: 57679)].
Alternate Names
ALS2CR6; alsin; ALSJ; amyotrophic lateral sclerosis 2 (juvenile); amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; amyotrophic lateral sclerosis 2 protein; IAHSP; PLSJ
Applications