Rabbit anti-CD2AP Antibody
Catalog #
CD2AP
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 689 and 639
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
CD2-associated protein (CD2AP) seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, it modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. It also controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. CD2AP may play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell and may anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. CD2AP is also required for cytokinesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5K6].
Alternate Names
adapter protein CMS; cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein; CMS
Applications