Rabbit anti-STAT3 Recombinant Monoclonal Antibody [BLR098G]
Catalog #
STAT3
Human
,Mouse
Flow Cyt
,ICC
,IHC
,IP
,WB
Rabbit
Recombinant Monoclonal
BLR098G
Whole IgG
between 175 and 225
IgG
Unconjugated
Purified
Product Details
Human,
Mouse
Human
2 - 8 °C
1 year from date of receipt
STAT3 (signal transducer and activator of transcription 3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein [taken from NCBI Entrez Gene (GeneID:6774)].
Signal transducer and activator of transcription 3
Alternate Names
acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; HIES; signal transducer and activator of transcription 3
Applications