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Rabbit anti-GTF2I/TFII-I IHC Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
GTF2I/TFII-I
Reactivity:
Human, Mouse
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 985 and 998
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (50+ slides)

10 µl (5+ slides)

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Product Details

Specifications
Verified Reactivity
Mouse, Human
Presumed Reactivity
White-tufted-ear marmoset, Tasmanian devil, Crab-eating macaque, Panda, Monkey, Pig, Small-eared galago, Guinea pig_10141, Little brown bat, Thirteen-lined ground squirrel, Gray short-tailed opossum, Chimpanzee, Northern white-cheeked gibbon, Dog, Bovine, Orangutan, Horse, Rat
Antigen Species
Human
Stock Concentration
100 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to GTF2I/TFII-I immobilized on solid support.

The epitope recognized by IHC-00273-T maps to a region between residue 985 and 998 of human general transcription factor II-I using the numbering given in entry NP_127492.1 (GeneID 2969).

Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

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Gene & Protein Information

GTF2I/TFII-I is a multi-functional transcription factor that interacts with the basal transcription machinery and links upstream cellular signals to responsive activator complexes that associate with the C-FOS promoter and other response elements. Haploinsufficiency of GTF2I/TFII-I results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.

2969

GTF2I

general transcription factor IIi

P78347

General transcription factor II-I

Alternate Names

BAP135, BAP-135, Bruton tyrosine kinase-associated protein 135, BTKAP1, BTK-associated protein 135, BTK-associated protein, 135kD, DIWS, general transcription factor II-I, GTFII-I, IB291, SPIN, SRF-Phox1-interacting protein, TFII-I, WBS, WBSCR6, Williams-Beuren syndrome chromosomal region 6 protein, Williams-Beuren syndrome chromosome region 6

Applications

Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated.