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Rabbit anti-NSD1 IHC Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
NSD1
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 650 and 700
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (50+ slides)

10 µl (5+ slides)

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Product Details

Specifications
Verified Reactivity
Human
Antigen Species
Human
Stock Concentration
250 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to NSD1 immobilized on solid support.

The epitope recognized by IHC-00027-T maps to a region between residue 650 and 700 of human NSD1 using the numbering given in SwissProt entry Q96L73 (GeneID 64324).

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Gene & Protein Information

NSD1 is a histone methyltransferase that preferentially methylates Lys-36 of histone H3 and Lys-20 of histone H4. NSD1 can function as an androgen receptor coactivator and is capable of both negatively and positively influencing transcription. Mutations in NSD1 are responsible for Sotos syndrome, Weaver syndrome, Beckwith-Wiedemann syndrome, and a form of childhood leukemia.

64324

NSD1

nuclear receptor binding SET domain protein 1

Q96L73

Histone-lysine N-methyltransferase, H3 lysine-36 a

Alternate Names

androgen receptor coactivator 267 kDa protein, androgen receptor-associated coregulator 267, androgen receptor-associated protein of 267 kDa, ARA267, H3-K36-HMTase, H4-K20-HMTase, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, KMT3B, lysine N-methyltransferase 3B, NR-binding SET domain-containing protein, nuclear receptor SET domain-containing protein 1, nuclear receptor-binding SET domain-containing protein 1, SOTOS, SOTOS1, STO

Applications

Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated.