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Rabbit anti-ASC2 IHC Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
ASC2
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 2000 and C-term
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (50+ slides)

10 µl (5+ slides)

For ordering information, see our International Distributors

Product Details

Specifications
Verified Reactivity
Human
Presumed Reactivity
White-tufted-ear marmoset, Crab-eating macaque, Panda, Monkey, African elephant, Guinea pig_10141, Little brown bat, Thirteen-lined ground squirrel, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Dog, Horse
Antigen Species
Human
Stock Concentration
250 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to ASC2 immobilized on solid support.

The epitope recognized by IHC-00019-T maps to a region between residue 2000 and the C-terminus (residue 2063) of human Activating Signal Cointegrator-2 using the numbering given in Swiss-Prot entry Q14686 (GeneID 23054).

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Gene & Protein Information

Activating signal co-integrator 2 (ASC2) functions as a hormone-dependent transcriptional coactivator in cooperation with nuclear receptors such as steroids, retinoids, thyroid hormone, vitamin D3 and prostanoids. ASC2 also interacts with basal transcription factors and may also influence gene expression through its association with histone modifiers. ASC2 has been identified as an amplified gene in breast and other human cancers.

23054

NCOA6

nuclear receptor coactivator 6

Q14686

Nuclear receptor coactivator 6

Alternate Names

Activating signal cointegrator 2, activating signal cointegrator-2, AIB3, amplified in breast cancer protein 3, amplified in breast cancer-3 protein, ASC2, ASC-2, cancer-amplified transcriptional coactivator ASC-2, NRC, NRC RAP250, nuclear receptor coactivator 6, nuclear receptor coactivator RAP250, nuclear receptor-activating protein, 250 kDa, peroxisome proliferator-activated receptor interacting protein, Peroxisome proliferator-activated receptor-interacting protein, PPAR-interacting protein, PRIP, RAP250, thyroid hormone receptor binding protein, Thyroid hormone receptor-binding protein, TRBP

Applications

Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated.