Rabbit anti-B-Myb IHC Antibody Affinity Purified

Product Details
Specifications
The epitope recognized by IHC-00604 maps to a region between residue 450 and 500 of human MYB-related protein B using the numbering given in entry NP_002457.1 (GeneID 4605).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to B-Myb immobilized on solid support.
The epitope recognized by IHC-00604-T maps to a region between residue 450 and 500 of human MYB-related protein B using the numbering given in entry NP_002457.1 (GeneID 4605).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Additional Product Information
B-myb is transcription factor involved in multiple cellular processes such as cell survival, proliferation, and differentiation. B-myb was identified in a low-stringency screen of a T-cell cDNA library probed with a C-myb probe. C-myb is a cellular proto-oncogene highly conserved in vertebrates and invertebrates. The chicken c-myb proto-oncogene was the first ortholog discovered. Investigation of the origins of the avian myeloblastosis virus (AMV) led to the discovery that the AMV genome contained transduced sequences from normal chicken cellular DNA that resulted in a viral oncogenic version (v-myb) of the c-myb gene. B-myb is cell cycle regulated and expressed in all proliferating cells. Recent studies show that it is the only myb family member detected in embryonic stem cells and is essential to cell cycle progression and genomic stability.
Alternate Names
BMYB; B-MYB; myb-like protein 2; myb-related protein B; v-myb avian myeloblastosis viral oncogene homolog-like 2; v-myb myeloblastosis viral oncogene homolog-like 2
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.