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Rabbit anti-CDK7 Recombinant Monoclonal Antibody [BL-80-5D4]

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
CDK7
Reactivity:
Human
Host:
Rabbit
Clonality:
Recombinant Monoclonal
Clone:
BL-80-5D4
Format:
Whole IgG
Immunogen:
between 300 and 346 (C-term)
IsoType:
IgG
Purity:
Purified
100 µl (10 blots)

20 µl (2 blots)

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Product Details

Specifications
Verified Reactivity
Human
Antigen Species
Human
Stock Concentration
40 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Recombinant antibody was purified from cell culture supernatant.

The epitope recognized by A700-006-T maps to a region between residues 300 and the C-terminus (residue 346) of human Cyclin-Dependent Kinase 7 using the numbering given in Swiss-Prot entry P50613 (GeneID 1022).

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Gene & Protein Information

Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK7 is the catalytic subunit in a trimeric complex with cyclin H and MAT1 that functions as a Cdk-activating kinase (CAK). CDK7 activates the kinase activities of CDK1, CDK2, CDK4, and CDK6 by threonine phosphorylation. In addition to its cell cycle function CDK7 has also been found to be an essential component of the transcription factor TFIIH. Several substrates of CDK7 are involved in transcription, further indicating a role in transcription.

1022

CDK7

cyclin dependent kinase 7

P50613

Cyclin-dependent kinase 7

Alternate Names

39 KDa protein kinase, CAK, CAK1, CDK-activating kinase 1, CDKN7, cell division protein kinase 7, cyclin-dependent kinase 7, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase), HCAK, homolog of Xenopus MO15 Cdk-activating kinase, kinase subunit of CAK, MO15, p39 Mo15, p39MO15, serine/threonine kinase stk1, serine/threonine protein kinase 1, serine/threonine protein kinase MO15, Serine/threonine-protein kinase 1, STK1, TFIIH basal transcription factor complex kinase subunit