Rabbit anti-CRM1 IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00139 maps to a region between residues1025 and the C-terminus (residue 1071) of human Chromosome Region Maintenance 1 (Exportin 1) using the numbering given in entry NP_003391.1 (GeneID 7514). Antibody was affinity purified using an epitope specific to CRM1 (Exportin 1) immobilized on solid support.
The epitope recognized by IHC-00139-T maps to a region between residues1025 and the C-terminus (residue 1071) of human Chromosome Region Maintenance 1 (Exportin 1) using the numbering given in entry NP_003391.1 (GeneID 7514).
Additional Product Information
Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.
Alternate Names
chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; CRM1; emb; exp1; exportin 1 (CRM1 homolog, yeast); exportin-1; exportin-1 (required for chromosome region maintenance)
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.