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Rabbit anti-CSN3 IHC Antibody Affinity Purified

bethyl
Bethyl Laboratories Catalog #
Validated
Target:
CSN3
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 373 and C-terminus
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Antigen Affinity Purified
100 µl (50+ slides)

10 µl (5+ slides)

$131.00 $492.00
Qty:

Product Details

Specifications

Verified Reactivity
Human
Presumed Reactivity
Guinea Pig, Mouse, Horse, Zebra Finch, Turkey, Dog, Chicken, X. tropicalis, Bovine, Monkey, Rat
Antigen Species
Human
Concentration
250 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Production Procedures
Antibody was affinity purified using an epitope specific to CSN3 immobilized on solid support.

The epitope recognized by IHC-00111 maps to a region between residues residues 325 and 375 of human COP9 constitutive photomorphogenic homolog subunit 3 using the numbering given in entry NP_003644.2 (GeneID 8533).
Antibody was affinity purified using an epitope specific to CSN3 immobilized on solid support.

The epitope recognized by IHC-00111-T maps to a region between residues residues 325 and 375 of human COP9 constitutive photomorphogenic homolog subunit 3 using the numbering given in entry NP_003644.2 (GeneID 8533).
Country of Origin
USA

Additional Product Information

CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.

8533
COPS3
COP9 signalosome subunit 3
Q9UNS2
COP9 signalosome complex subunit 3

Alternate Names

COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 signalosome complex subunit 3; CSN3; JAB1-containing signalosome subunit 3; SGN3; signalosome subunit 3

Applications

Epitope exposure is recommended.

Epitope exposure with citrate buffer will enhance staining.

Likely to work with frozen sections.

In some cases, the antibody may be diluted further than indicated.