Rabbit anti-FUS Recombinant Monoclonal Antibody [BLR023E]
Catalog #
FUS
Human
,Mouse
ICC-IF
,IHC
,IHC-IF
,IP
,WB
COMET™
Rabbit
Recombinant Monoclonal
BLR023E
Whole IgG
Between 1 and 50
IgG
Unconjugated
Purified
Product Details
Mouse,
Human
Human
Human
2 - 8 °C
1 year from date of receipt
Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
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Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free
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Recombinant antibody was purified from cell culture supernatant.
Immunogen was a peptide representing a region between residues 1 and 50 of human fusion (involved in t(12;16) in malignant liposarcoma) using the numbering given in SwissProt entry P35637 (GeneID 2521).
USA
FUS has been identified as a frequent translocation fusion partner of various transcription factors. FUS fusion genes have been shown to be associated with multiple tumor types which include liposarcoma, leukemia, histocytoma, and sarcoma. FUS is a multifunctional RNA-binding protein that associates with the nuclear matrix and Cajal bodies and appears to play a role in splicesome assembly, pre-mRNA splicing, DNA repair, transcriptional regulation and homologous recombination.
Alternate Names
75 kDa DNA-pairing protein; ALS6; ETM4; FUS/ERG chimeric protein; FUS/ERG fusion protein; FUS1; fused in sarcoma; fusion gene in myxoid liposarcoma; fus-like protein; heterogeneous nuclear ribonucleoprotein P2; HNRNPP2; oncogene FUS; oncogene TLS; POMP75; RNA-binding protein FUS; TLS; translocated in liposarcoma protein
Applications