Rabbit anti-GRB10 IHC Antibody
Catalog #
GRB10
Human
IHC
Rabbit
Polyclonal
Whole IgG
Between 100 and 150
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Monkey
Human
2 - 8 °C
1 year from date of receipt
Growth factor receptor-bound protein 10 (GRB10) is a member of a family of adaptor proteins that bind to a variety of growth factor receptors to regulate receptor signaling and mediate signals for a variety of processes such as metabolism, growth, apoptosis, and migration. As a dimer, via its BPS (between PH and SH2) and SH2 (src-homology 2) domains, GRB10 associates with the insulin receptor (IR) as well as the insulin-like growth factor receptor (IGFR). GRB10’s association with the IR has been shown to have inhibitory effects on insulin-induced kinase signaling; however studies have also reported that GRB10 can also have positive effects on IR signaling. It is suggested that GRB10 can serve in cellular functions independent of an interaction with the IR.
Alternate Names
Grb-10; GRB10 adapter protein; GRB10 adaptor protein; GRB-IR; growth factor receptor-bound protein 10; insulin receptor-binding protein Grb-IR; IRBP; maternally expressed gene 1; MEG1; RSS
Applications
