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Rabbit anti-GTF2IRD/TFII-IRD1 IHC Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
GTF2IRD/TFII-IRD1
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 650 and 700
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (50+ slides)

10 µl (5+ slides)

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Product Details

Specifications
Verified Reactivity
Human
Presumed Reactivity
Panda, Pig, Gorilla, Chimpanzee, Dog, Bovine, Orangutan, Horse
Antigen Species
Human
Stock Concentration
100 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to GTF2IRD/TFII-IRD1 immobilized on solid support.

The epitope recognized by IHC-00274-T maps to a region between residue 650 and 700 of human general transcription factor 2I repeat domain containing 1 using the numbering given in entry NP_057412.1 (GeneID 9569).

Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

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Gene & Protein Information

GTF2IRD1/TFII-IRD1 possesses five helix-loop-helix GTF2I-like repeats and has been shown to bind the GUCE (GTF2IRD1 upstream response element) regulatory motif found in HOXC8, GOOSECOID, and TROPONININ (SLOW) genes. GTF2IRD1/TFII-IRD1 may be involved in skeletal muscle differentiation and myogenesis. Haploinsufficiency of GTF2IRD1/TFII-IRD1 results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.

9569

GTF2IRD1

GTF2I repeat domain containing 1

Q9UHL9

General transcription factor II-I repeat domain-co

Alternate Names

BEN, binding factor for early enhancer, CREAM1, general transcription factor 3, general transcription factor III, general transcription factor II-I repeat domain-containing protein 1, GTF2I repeat domain-containing protein 1, GTF3, hMusTRD1alpha1, Muscle TFII-I repeat domain-containing protein 1, muscle TFII-I repeat domain-containing protein 1 alpha 1, MUSTRD1, MusTRD1/BEN, RBAP2, slow-muscle-fiber enhancer-binding protein, USE B1-binding protein, WBS, WBSCR11, WBSCR12, Williams-Beuren syndrome chromosomal region 11 protein, williams-Beuren syndrome chromosomal region 12 protein, Williams-Beuren syndrome chromosome region 11

Applications

Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated.