Rabbit anti-LCP2/SLP76 Antibody Affinity Purified
Catalog #
LCP2/SLP76
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 200 and 250
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Lymphocyte cytosolic protein 2 (LCP2) was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. LCP2 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with LCP2 both constitutively and inducibly following receptor ligation, supporting the notion that LCP2 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that LCP2 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function [taken from NCBI Entrez Gene (Gene ID: 3937)].
Alternate Names
76 kDa tyrosine phosphoprotein; lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP76; SLP-76; SLP-76 tyrosine phosphoprotein
Applications