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Rabbit anti-MAVS/VISA Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
MAVS/VISA
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 150 and 200
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (200 µg/ml)

100 µl (10 blots)

20 µl (2 blots)

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Product Details

Specifications
Verified Reactivity
Human
Antigen Species
Human
Stock Concentration
40 µg/ml
200 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to MAVS/VISA immobilized on solid support.

The epitope recognized by A300-782A-T maps to a region between residue 150 and 200 of human Mitochondrial Anti-Viral Signaling Protein (Virus-Induced Signaling Adapter) using the numbering given in entry AAH44952.1 (GeneID 57506).

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Gene & Protein Information

Mitochondrial Antiviral-Signaling Protein (MAVS), also known as Virus-Induced Signaling Adaptor (VISA), is an adaptor protein that functions in the activation of the nuclear factor KappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) to mediate host innate immune responses against double-stranded RNA viral infection. MAVS (VISA) is localized to the outer mitochondrial membrane. Hepatitis C virus NS3/4A protease cleaves MAVS as part of an immune-evasion strategy.

57506

MAVS

mitochondrial antiviral signaling protein

Q7Z434

Mitochondrial antiviral-signaling protein

Alternate Names

CARD adapter inducing interferon beta, CARD adaptor inducing IFN-beta, CARDIF, IFN-B promoter stimulator 1, interferon beta promoter stimulator protein 1, IPS1, IPS-1, MAVS, mitochondrial antiviral-signaling protein, putative NF-kappa-B-activating protein 031N, virus-induced signaling adaptor, virus-induced-signaling adapter, VISA

Applications

Western blot of immunoprecipitates performed using Normal Pig Serum (Cat. No. S100-020), Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) and 4-20% SDS-PAGE. Western blot of lysates performed using standard western blot reagents and 4-20% SDS-PAGE.

Citations (12)