Rabbit anti-MCM4 IHC Antibody Affinity Purified

Product Details
Specifications
The epitope recognized by IHC-00039 maps to a region between residue 750 and 800 of human Minichromosome Maintenance 4 using the numbering given in entry NP_005905.2 (GeneID 4173). Antibody was affinity purified using an epitope specific to MCM4 immobilized on solid support.
The epitope recognized by IHC-00039-T maps to a region between residue 750 and 800 of human Minichromosome Maintenance 4 using the numbering given in entry NP_005905.2 (GeneID 4173).
Additional Product Information
The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM4 is part of the core MCM complex that includes MCM4, MCM6, and MCM7. The core complex possesses DNA helicase activity. MCM4 is phosphorylated by CDC2 kinase resulting in a reduction of helicase activity and chromatin binding.
Alternate Names
CDC21; CDC21 homolog; CDC54; DNA replication licensing factor MCM4; hCdc21; homolog of S. pombe cell devision cycle 21; IMD54; minichromosome maintenance deficient 4; NKCD; NKGCD; P1-CDC21
Applications
Epitope exposure is recommended.