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Rabbit anti-OSR1 Antibody Affinity Purified

bethyl
Bethyl Laboratories Catalog #
Validated
Target:
OSR1
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 300 and 350
Isotype:
IgG
Conjugate:
Unconjugated
Purity:
Antigen Affinity Purified
100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

$131.00 $464.00
Qty:

Product Details

Specifications

Verified Reactivity
Human
Antigen Species
Human
Concentration
1000 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
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Production Procedures
Antibody was affinity purified using an epitope specific to OSR1 immobilized on solid support.

The epitope recognized by A301-578A-T maps to a region between residue 325 and 375 of human oxidative-stress responsive 1 using the numbering given in entry NP_005100.1 (GeneID 9943).

Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to OSR1 immobilized on solid support.

The epitope recognized by A301-578A maps to a region between residue 325 and 375 of human oxidative-stress responsive 1 using the numbering given in entry NP_005100.1 (GeneID 9943).

Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Country of Origin
USA

Additional Product Information

Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.

9943
OXSR1
oxidative stress responsive 1
O95747
Serine/threonine-protein kinase OSR1

Alternate Names

OSR1; oxidative stress-responsive 1 protein; serine/threonine-protein kinase OSR1

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.