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Rabbit anti-PD-L1 Recombinant Monoclonal Antibody [BLR020E]

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
PD-L1
Reactivity:
Human
Host:
Rabbit
Clonality:
Recombinant Monoclonal
Clone:
BLR020E
Format:
Whole IgG
Immunogen:
between 250 to 290 (C-term)
IsoType:
IgG
Purity:
Purified
100 µl (50+ tests)

10 µl (5+ tests)

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Product Details

Specifications
Verified Reactivity
Human
Antigen Species
Human
Stock Concentration
50 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Recombinant antibody was purified from cell culture supernatant.

Immunogen was a synthetic peptide representing a region between residue 250 and the C-terminus (residue 290) of human programmed cell death 1 ligand 1 (PD-L1) according to the numbering given in entry NP_054862.1 (GeneID 29126).

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Gene & Protein Information

PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].

29126

CD274

CD274 molecule

Q9NZQ7

Programmed cell death 1 ligand 1

Alternate Names

B7 homolog 1, B7-H, B7H1, B7-H1, CD antigen CD274, CD274 antigen, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, programmed cell death 1 ligand 1, Programmed death ligand 1