Rabbit anti-Phospho XRCC1 (S461) IHC Antibody Affinity Purified

Product Details
Specifications
The epitope recognized by IHC-00116 maps to a region surrounding residue Ser 416 of human X-ray Repair Complementing protein 1 using the numbering given in SwissProt entry P18887 (GeneID 7515). Antibody was affinity purified using an epitope specific to Phospho XRCC1 (S461) immobilized on solid support.
The epitope recognized by IHC-00116-T maps to a region surrounding residue Ser 416 of human X-ray Repair Complementing protein 1 using the numbering given in SwissProt entry P18887 (GeneID 7515).
Additional Product Information
X-ray repair cross-complementing protein 1 (XRCC1) has been identified as a gene that partially rescues a DNA repair defect and therefore plays a role in efficient repair of single-stranded breaks in DNA damage caused by ionizing radiation. XRCC1 interacts with human polynucleotide kinase, DNA polymerase-beta, and DNA ligase III in a multiprotein complex to execute the function of DNA repair.
Alternate Names
DNA repair protein XRCC1; RCC; SCAR26; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.