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Rabbit anti-PPP1CC IHC Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
PPP1CC
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 280 and C-term
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (50+ slides)

10 µl (5+ slides)

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Product Details

Specifications
Verified Reactivity
Human
Presumed Reactivity
Murinae, West Indian ocean coelacanth, Duckbill platypus, Green anole, Zebra finch, White-tufted-ear marmoset, Tasmanian devil, Crab-eating macaque, Panda, Monkey, African elephant, Pig, X. laevis, Guinea pig_10141, Little brown bat, Northern white-cheeked gibbon, Dog, Bovine, Horse, Rat, Mouse, X. tropicalis
Antigen Species
Human
Stock Concentration
250 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to PPP1CC immobilized on solid support.

The epitope recognized by IHC-00485-T maps to a region between residue 280 and the C-terminus (residue 323) of human Protein Phosphatase 1, Catalytic Subunit, Gamma Isoform using the numbering given in entry NP_002701.1 (GeneID 5501).

Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

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Gene & Protein Information

Protein phosphatase 1 (PP1) is a major eukaryotic serine/threonine phosphatase that is involved in a multitude of cellular functions. PP1 is a holoenzyme that consists of the PP1 catalytic subunit (PP1c) that associates with and is regulated by over 50 regulatory subunits. There are several gene and alternative splice products of the catalytic subunit PP1c. PPP1CC encodes the PP1 gamma catalytic subunit. In addition to PP1 gamma, there are two splice variants of PP1 alpha (PPP1CA), and a PP1 beta (PPP1CB) form. The mutually exclusive interaction between the various catalytic and regulatory subunits allows the PP1 enzyme to be involved in a variety of functions which include cell division, glycogen metabolism, muscle contractility, and protein synthesis. serine/threonine-protein phosphatase PP1-gamma catalytic subunit, PP-1G, PPP1G.

5501

PPP1CC

protein phosphatase 1 catalytic subunit gamma

P36873

Serine/threonine-protein phosphatase PP1-gamma cat

Alternate Names

PP1C, PP-1G, PPP1G, protein phosphatase 1, catalytic subunit, gamma isoform, protein phosphatase 1, catalytic subunit, gamma isozyme, protein phosphatase 1C catalytic subunit, serine/threonine phosphatase 1 gamma, serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Applications

Epitope exposure is recommended. Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated.

Citations (1)