Bethyl Laboratories
Rabbit anti-PZR Antibody Affinity Purified
Primary
Catalog #A304-411A
TargetPZR
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIP, WB
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Product Description
Protein zero-related (PZR) is a cell surface receptor involved in signal transduction processes. PZR recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. It is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95297].
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 219 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetPZR
Antigen Species
Human
Gene ID9019
Gene Symbol
MPZL1
Gene Name
myelin protein zero like 1
Uniprot IDO95297
Protein Name
Myelin protein zero-like protein 1
Alternate Names
Product Information
Applications
IP, WB
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to PZR immobilized on solid support.
The epitope recognized by A304-411A maps to a region between residue 225 to 275 of human Protein Zero Related using the numbering given in entry NP_003944.1 (GeneID 9019).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (A120-101P).
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.
Immunoprecipitation (IP)6 µg/mg lysate
Western Blot (WB)1:2000 - 1:10,000
Documents
Product DatasheetPDF · A304-411A · Lot 1 (current lot)Open
Product DatasheetPDF · A304-411A · Lot 1 (current lot)Open
Safety Data SheetPDF · A304-411AOpen
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