Rabbit anti-SNUPN Antibody Affinity Purified

Product Details
Specifications
The epitope recognized by A305-568A maps to a region between residue 310 to 360 of human Snurportin-1 using the numbering given in entry O95149.1 (GeneID 10073).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4. Antibody was affinity purified using an epitope specific to SNUPN immobilized on solid support.
The epitope recognized by A305-568A-T maps to a region between residue 310 to 360 of human Snurportin-1 using the numbering given in entry O95149.1 (GeneID 10073).
Additional Product Information
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. Snurportin-1 (SNUPN) interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor [taken from NCBI Entrez Gene (Gene ID: 10073)].
Alternate Names
KPNBL; RNA U transporter 1; RNUT1; Snurportin1; snurportin-1
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.