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PathPlex® IHC Panels

Fortis Life Sciences provides high-quality reverse transcription (RT) kits developed for reliable results in RT-PCR and RT-qPCR applications. Our solutions support cDNA synthesis and one-step RT-qPCR, enabling critical research in gene expression, pathogen detection, and diagnostic assay development.

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Fortis Life Sciences offers a range of standard and custom monoclonal antibodies, available for a wide range of immunoassay applications.

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AbNano™ VHH Libraries

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Products

The hypoxic response pathway is triggered by low levels of oxygen in the cellular environment. Hypoxia inducible transcription factor (HIF) is central to the hypoxic response. HIF exists as a heterodimeric transcription factor composed of an alpha and beta subunit.

Hypoxia Signaling: HIF1-alpha & HIF2-alpha Recombinant Rabbit Monoclonal Antibodies

The hypoxic response pathway is triggered by low levels of oxygen in the cellular environment. Hypoxia inducible transcription factor (HIF) is central to the hypoxic response. HIF exists as a heterodimeric transcription factor composed of an alpha and beta subunit. In mammals there are three HIF-alpha subunits, HIF1-alpha, HIF2-alpha, and HIF3-alpha, and one beta subunit, the aryl hydrocarbon receptor nuclear translocator (ARNT). The overexpression of HIF1-alpha and HIF2-alpha is associated with poor survival rates for various cancers. Experimental and clinical evidence strongly suggests HIF1-alpha and HIF2-alpha influence tumor development and response to treatment. Because of this, there has been major interest in developing selective HIF inhibitors; but due to the complexity of the HIF pathway, the process has been challenging. Thus, future work for therapeutic targeting of the HIFs will require a better understanding of both the HIF1-alpha and HIF2-alpha pathways.

Resource Type

Field

Research Area

BETHYL-A301-305 from Bethyl Laboratories. Polyclonal Rabbit anti-DOCK10 Antibody. Validated for: IP,WB. Derived using an immunogen from Between 125 and 175.