De-Risk Antibody Programs Across Your Portfolio
You need an antibody development partner who can deliver consistent results on predictable timelines.
Fortis Life Sciences is a vertically integrated, Farm to Bench partner that unifies Bethyl’s validated antibody development, Abcore’s VHH and recombinant engineering, and Arista’s assay‑ready reagents into one workflow, reducing biological risk and technical variability so antibodies perform consistently from early discovery through successful development.
Mitigating Discovery Risks Early
Antibody-related risks tend to appear at predictable points. Ignoring them can derail your timeline and budget.
Common Sources of Risk
- Targets advance without sufficient orthogonal validation
- Assay-specific antibody performance that fails to transfer
- Reproducibility erodes across sites, teams, or reagent lots
- Batch variability undermine longitudinal or comparative studies
- Manufacturability constraints emerging after key data are generated
- Biological relevance inferred without tissue-level confirmation
Fortis applies predefined controls at each stage to help you identify and address these risks early, while programs remain flexible and evidence gaps can still be closed efficiently.
Accelerate Your Antibody Programs
Success depends on turning risk insights into standardized practices and a connected ecosystem that keeps antibody discovery predictable, reproducible, and scalable.
Fortis does this with a Farm to Bench model, partnering with you to optimize physical capacity, supply‑chain, immunization, antigen design, production, recombinant cloning, and assay validation.
Integrated services keep every step within a single network, helping teams manage timelines, use budgets more efficiently, and base decisions on consistently high‑quality data.
Maximize Infrastructure and Capacity
- 45,000 ft² of advanced laboratory space for antibody engineering, screening, and validation
- 15,000 ft² of on-site large-animal facilities and 1000 acres of pasture, with additional acreage available for expansion
- Care for 10 on-site species, enabling species selection tailored to antigen class and immunogenicity requirements
Secure Your Supply Chain
- In-house manufacturing and validation to maintain control over production variables and QC
- Vertically integrated operations from antigen through final antibody format, without reliance on external supply chains
- Scalable supply aligned to individual program demands and portfolio-level priorities
Farm to Bench Control
1. Target Validation and Modality Selection
Keep target and format risk low before you scale.
What We Can Do for You
Validate target and antigen quality
- Confirm sequence and structure with recombinant expression and controlled purification.
- Verify post-translational and structural context with capture mass spectrometry where appropriate.
Quantify specificity and epitope risk
- Generate independent antibodies to non-overlapping epitopes.
- Detect epitope-dependent artifacts that only appear in specific assays or conditions.
Decide VHH vs IgG with data
- Apply VHH single-domain antibody screening to recessed or cryptic epitopes.
- Advance VHH or recombinant IgG based on stability and performance in your matrices.
PROOF IN PRACTICE
EpiCypher and Bethyl Laboratories developed custom antibodies for histone post-translational modifications in complex chromatin environments, using orthogonal controls and a dual-stage screen to deliver publication-ready candidates.
2. Development and Multi-Format Validation
Turn one antibody decision into tools every team can use.
What We Can Do for You
Generate multi-use reagents from a single immunization
- Design immunization strategies that feed your discovery, translational, and biomarker workflows.
- Use our farm-to-bench network to anticipate cross-team needs and avoid redundant antibody generation.
Validate during development, not after handoff
- Qualify performance in your key assays before reagents move to additional teams or sites.
- Resolve issues during development so methods do not need to be rebuilt later.
Apply validation standards
- Use our Six Pillars of Validation so data are comparable across studies and meet defined standards for specificity, reproducibility, and performance.
Engineer antibody properties instead of restarting programs
- Tune stability, affinity, isotype, and conjugation while preserving paratope specificity with recombinant platforms and VHH capabilities.
PROOF IN PRACTICE
NextPoint Therapeutics used a single recombinant antibody platform with Bethyl to explore multiple immune checkpoint axes, validating candidates across functional assays, tissue imaging, and flow cytometry without duplicating reagent generation.
3. Manufacturing Readiness and Biological Validation
Prove your discovery antibody will behave in production and in tissue.
What We Can Do for You
Run pilot lots under scale-ready conditions
- Confirm batch consistency and formulation before moving to full-scale manufacturing..
Align validation with downstream applications
- Use IHC and multiplex spatial panels on your target tissues to confirm on-target engagement in relevant pathology.
- Apply knockout or knockdown models to verify specificity in living systems.
Keep manufacturability predictive, not theoretical
- Integrate antibody production under validated Bethyl processes so early manufacturability data remain predictive at scale.
- Apply predefined verification steps to lock in critical process parameters and shorten time to manufacturing readiness.
PROOF IN PRACTICE
Valted Seq used Bethyl’s custom recombinant antibody development services to address biomarker challenges in neurodegenerative disease. Spatial imaging during manufacturing validation confirmed target engagement in patient tissues, while disease-model genetics confirmed specificity in relevant pathways. This convergence enabled rapid biomarker qualification and accelerated diagnostic development.
Deliver on This Year's Critical Milestones
We can map an end-to-end antibody strategy based on your priority indications, critical readouts, and timeline goals. Our Farm to Bench services cover modality selection, validation pillars, and manufacturing readiness to minimize technical risk, accelerate readiness, and keep your timelines on track.
