Podcast: Mitochondria, the immune system and cancer- discovering new insights with spatial technologies

In this podcast, produced in collaboration with BioTechniques, we delve into the relationship between mitochondria, inflammation and cancer, discussing the new techniques that are bearing fruit in this field, such as spatial analysis.

Our expert insight for this episode comes from Dr. Phillip West, formerly Principal Investigator of the West lab at Texas A&M Medicine (TX, USA) and now at The Jackson Laboratory. He explains the role mitochondria can play in cancer and heart disease, reveals some of his most exciting discoveries of late and provides technical tips for investigating this field.

Listen on to discover how his use of spatial techniques has helped uncover mechanisms linking mitochondrial damage to the stifling of the immune system in the tumor microenvironment and the latest breakthroughs at the intersection of mitochondria and cancer.

Contents

• Introduction: 00:00-01:30
• The innate immune system, in inflammation and disease: 01:30-04:20
• The role of mitochondria in innate immunity: 04:20-07:00
• Categorizing DAMPS and their role in cardiovascular disease: 07:00-08:40
• Mitochondria and cancer: 08:40-11:55
• Techniques for the investigation of mitochondria: 11:55-15:20
• Best practice techniques for spatial studies: 15:20-17:35
• Discoveries made using spatial approaches to mitochondrial investigations: 17:35-19:55
• The latest developments in the intersection of mitochondria, cancer and inflammation: 19:55-22:20
• What is one thing you would ask for to improve your understanding of this field? 22:20-24:20