Bethyl Laboratories
Purified Recombinant Human IgG4, kappaNew
Antigen Proteins
Catalog #P80-004
ClonalityRecombinant Monoclonal
ApplicationELISA
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Product Description
IgG4 represents only 2-5% of the human IgG subclasses in serum. IgG4 lacks effector functions, such as antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity. IgG4 plays a protective role in allergy by acting as a blocking antibody, and inhibiting mast cell degranulation, but a deleterious role in malignant melanoma, by impeding IgG1-mediated anti-tumor immunity.
Specifications
Clonality
Recombinant Monoclonal
Isotype
IgG4, kappa
Species
Human
Epitope Tag
None
Conjugate Type
Unconjugated
Purity
Purified
Concentration
1 mg/ml
Product Information
Applications
ELISA
Buffer
Phosphate Buffered Saline (PBS) with 0.09% Sodium Azide, BSA-Free
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody variable sequence derived from human anti CoV Spike antibody CR3022 (PMID: 32065055).
Antibody was produced by transient transfection in CHO cells.
Recombinant antibody was purified from cell culture supernatant by Protein G chromatography.
Applications
Used as a positive control in immunoassays.
Documents
Safety Data SheetPDF · P80-004Open
Product DatasheetPDF · P80-004 · Lot PA241118A (current lot)Open
Services
Antibody Conjugation
Antibody and conjugate formats developed together, built to your specification.
Request CustomizationCustom Monoclonal Antibody Discovery Services
Full custom monoclonal development, from immunization through validation.
Explore Monoclonal DevelopmentVHH Discovery
Single-domain antibodies for structurally difficult targets a conventional monoclonal can't reach.
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