Bethyl Laboratories
Rabbit anti-Phospho SMC1 (S966) IHC Antibody Affinity Purified
Primary
Catalog #IHC-00016
TargetSMC1 Phospho (S966)
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
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Product Description
Structural maintenance of chromosomes (SMC) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core cohesin complex includes a heterodimer of SMC1 and SMC3 that functions by forming a ring-like structure that holds sister chromatids together. Cohesin is important to sister chromatid separation and segregation during mitosis and meiosis and also plays a role in double-strand break repair by homologous recombination.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Surrounding serine 966
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetSMC1 Phospho (S966)
Antigen Species
Human
Gene ID8243
Gene Symbol
SMC1A
Gene Name
structural maintenance of chromosomes 1A
Uniprot IDQ14683
Protein Name
Structural maintenance of chromosomes protein 1A
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to Phospho-SMC1 (Ser 966) immobilized on solid support.
Immunogen for IHC-00016 was a phosphorylated synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes 1 (GeneID 8243) around serine 966 according to the numbering given in entry NP_006297.2.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00016Open
Product DatasheetPDF · IHC-00016 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00016 · Lot 1 (current lot)Open
Services
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