Bethyl Laboratories
Rabbit anti-CDK11 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00035
TargetCDK11
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
CDK11 is a member of the p34Cdc2 protein kinase family and is involved in cell cycle progression, apoptosis, and tumorigenesis. Many isoforms of CDK11 have been isolated. The p58 isoform has been shown to interact with cyclin D3 and to play an important role in G2/M phase progression. The p110 isoforms have been demonstrated to interact with the RNA-binding proteins RNPS1, RNA polymerase II, and many elongation factors, indicating a role in RNA metabolism in proliferating cells.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 745 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
500 µg/ml
Target Identity
TargetCDK11
Antigen Species
Human
Gene ID728642
Gene Symbol
CDK11A
Gene Name
cyclin dependent kinase 11A
Uniprot IDQ9UQ88
Protein Name
Cyclin-dependent kinase 11A
Alternate Names
CDC2L2 • CDC2L3 • CDK11-p110 • CDK11-p46 • CDK11-p58 • cell division cycle 2-like 2 (PITSLRE proteins) • cell division cycle 2-like protein kinase 2 • cell division protein kinase 11A • cyclin-dependent kinase 11A • galactosyltransferase-associated protein kinase p58/GTA • p58GTA • PITSLRE • PITSLRE B • PITSLRE protein kinase beta SV1 isoform • PITSLRE protein kinase beta SV16 isoform • PITSLRE protein kinase beta SV17 isoform • PITSLRE protein kinase beta SV18 isoform • PITSLRE protein kinase beta SV2 isoform • PITSLRE protein kinase beta SV3 isoform • PITSLRE protein kinase beta SV6 isoform • PITSLRE serine/threonine-protein kinase CDC2L2
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to CDK11 immobilized on solid support.
The epitope recognized by IHC-00035 maps to a region between residue 730 and the C-terminus (residue 780) of human Cell Division Cycle 2-like 2 using the numbering given in SwissProt entry Q9UQ88 (GeneID 728642). The epitope that is recognized by IHC-00035 is also found in CDC1L1 (Gene ID 984).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00035Open
Product DatasheetPDF · IHC-00035 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00035 · Lot 1 (current lot)Open
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