Bethyl Laboratories
Rabbit anti-REA IHC Antibody Affinity Purified
Primary
Catalog #IHC-00051
TargetREA
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
REA (repressor of estrogen receptor activity), also known as prohibitin 2, has been shown to exhibit a variety of functions that includes mitochondrial chaperone activity, cell cycle regulation, and transcriptional regulation. REA localizes to the mitochondria and associates with mitochondrial complex I where it may play a role in mitochondrial metabolism. REA interacts with pRb to inhibit E2F-mediated transcription as well as the estrogen receptor to repress estrogen-dependent transcription via recruitment of histone deacetylases.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1 and 50
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetREA
Antigen Species
Human
Gene ID11331
Gene Symbol
PHB2
Gene Name
prohibitin 2
Uniprot IDQ99623
Protein Name
Prohibitin-2
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to REA immobilized on solid support.
The epitope recognized by IHC-00051 maps to a region between residue 1 and 50 of human Repressor of Estrogen Activity (Prohibitin 2) using the numbering given in entry NP_009204.1 (GeneID 11331).
Applications
Epitope exposure is recommended.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00051Open
Product DatasheetPDF · IHC-00051 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00051 · Lot 1 (current lot)Open
Citations / Publications
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Resources
Standard Western Blot Protocol
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