Bethyl Laboratories
Rabbit anti-ASPM IHC Antibody Affinity Purified
Primary
Catalog #IHC-00058
TargetASPM
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationICC-IF
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Product Description
ASPM (abnormal spindle-like microcephaly associated) is also known as MCPH5 (autosomal recessive primary microcephaly 5). Defects in ASPM are the cause of microcephaly primary type 5 or microcephaly vera, an autosomal recessive disease characterized by reduced head circumference, small cerebral cortex, and reduced brain weight. At the cellular level, MCPH5 is important to mitotic spindle function and may play a preferential role in prenatal neurogenesis.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 3427 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetASPM
Antigen Species
Human
Gene ID259266
Gene Symbol
ASPM
Gene Name
abnormal spindle microtubule assembly
Uniprot IDQ8IZT6
Protein Name
Abnormal spindle-like microcephaly-associated protein
Product Information
Applications
ICC-IF
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to ASPM immobilized on solid support.
The epitope recognized by IHC-00058 maps to a region between residue 3425 and the C-terminus (residue 3477) of human ASP (Abnormal Spindle)-like, Microcephaly Associated using the numbering given in entry NP_060606.2 (GeneID 259266).
Applications
Formaldehyde-fixed cells: 1:100 - 1:500:
Permeabilization with Triton-X 100 is recommended.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunocytochemistry-Immunofluoresence (ICC-IF)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00058Open
Product DatasheetPDF · IHC-00058 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00058 · Lot 1 (current lot)Open
Citations / Publications
Services
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