Bethyl Laboratories
Rabbit anti-CDK5RAP2 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00063
TargetCDK5RAP2
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationICC-IF
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Product Description
Mutations in CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) have been linked to microcephaly. CDK5RAP2 may be involved in centrosome directed production of microtubules and mitotic spindle formation during neural cell division. CDK5RAP2 associates with the activating subunit of Cdk5, p25NCK5A. Cdk5 is a brain specific cyclin-dependent kinase important to mammalian brain development.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1843 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
500 µg/ml
Target Identity
TargetCDK5RAP2
Antigen Species
Human
Gene ID55755
Gene Symbol
CDK5RAP2
Gene Name
CDK5 regulatory subunit associated protein 2
Uniprot IDQ96SN8
Protein Name
CDK5 regulatory subunit-associated protein 2
Product Information
Applications
ICC-IF
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to CDK5RAP2 immobilized on solid support.
The epitope recognized by IHC-00063 maps to a region between residues 1843 and the C-terminus (residue 1893) of human CDK5 Regulatory Subunit Associated Protein 2 using the numbering given in entry NP_060719.4 (GeneID 55755).
Applications
Formaldehyde-Fixed Cells 1:100 - 1:500: Permeabilization with Triton-X 100 is recommended.
Methanol-Fixed Cells: 1:100 - 1:500.
Acetone fixation is not recommended.
Immunocytochemistry-Immunofluoresence (ICC-IF)Formaldehyde-Fixed Cells 1:100 - 1:500: Permeabilization with Triton-X 100 is recommended.<br><br>Methanol-Fixed Cells: 1:100 - 1:500.<br><br>Acetone fixation is not recommended.
Documents
Safety Data SheetPDF · IHC-00063Open
Product DatasheetPDF · IHC-00063 · Lot 2 (current lot)Open
Product DatasheetPDF · IHC-00063 · Lot 2 (current lot)Open
Citations / Publications
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