Bethyl Laboratories
Rabbit anti-SMARCA1/SNF2L IHC Antibody Affinity Purified
Primary
Catalog #IHC-00230
TargetSMARCA1/SNF2L
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. Member of this family have helicase and ATPase activities that alter chromatin structure to facilitate gene transcription. SMARCA1/SNF2L is a component of the human NURF (nucleosome remodeling factor) involved in the regulation of genes involved in neuronal development. SMARCA1/SNF2L is also a component of the heterodimeric complex CERF [CECR2(cat eye syndrome chromosome region, candidate 2)-containing remodeling factor].
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1004 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetSMARCA1/SNF2L
Antigen Species
Human
Gene ID6594
Gene Symbol
SMARCA1
Gene Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Uniprot IDP28370
Protein Name
Probable global transcription activator SNF2L1
Alternate Names
ATP-dependent helicase SMARCA1 • global transcription activator homologous sequence • hSNF2L • ISWI • nucleosome-remodeling factor subunit SNF2L • NURF140 • probable global transcription activator SNF2L1 • SNF2L • SNF2L1 • SNF2LB • SNF2-like 1 • SNF2LT • sucrose nonfermenting 2-like protein 1 • SWI • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 • SWI2
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to SMARCA1/SNF2L immobilized on solid support.
The epitope recognized by IHC-00230 maps to a region between residue 1004 and 1054 of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (sucrose nonfermenting 2-like 1) using the numbering given in entry NP_003060.2 (GeneID 6594).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00230Open
Product DatasheetPDF · IHC-00230 · Lot 2 (current lot)Open
Product DatasheetPDF · IHC-00230 · Lot 2 (current lot)Open
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