Bethyl Laboratories
Rabbit anti-FKBP4/FKBP52 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00290
TargetFKBP4/FKBP52
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC, IHC-IF
Image 1 of 1
local_shipping
Order within 5 hours and 33 minutes for shipment by today
Product Description
FKBP4/FKBP52 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP52 exhibits peptidyl-prolyl cis-trans isomerase activity, but does not appear to mediate the immunosuppressive activities of FK506. The most studied role of FKBP4/FKBP52 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperone Hsp90, FKBP4/FKBP52 is able to influence steroid-hormone binding affinity and transcriptional activity.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1 and 50
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetFKBP4/FKBP52
Antigen Species
Human
Gene ID2288
Gene Symbol
FKBP4
Gene Name
FK506 binding protein 4
Uniprot IDQ02790
Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP4
Alternate Names
51 kDa FK506-binding protein • 52 kDa FK506-binding protein • 52 kDa FKBP • 59 kDa immunophilin • FK506 binding protein 4, 59kDa • FK506-binding protein 4 • FKBP-4 • FKBP51 • FKBP52 • FKBP-52 • FKBP59 • HBI • HSP binding immunophilin • Hsp56 • HSP-binding immunophilin • Immunophilin FKBP52 • p52 • p59 • peptidylprolyl cis-trans isomerase • peptidyl-prolyl cis-trans isomerase FKBP4 • PPIase • PPIase FKBP4 • rotamase • T-cell FK506-binding protein, 59kD
Product Information
Applications
IHC, IHC-IF
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to FKBP4/FKBP52 immobilized on solid support.
The epitope recognized by IHC-00290 maps to a region between residue 1 and 50 of human FK506 binding protein 4 using the numbering given in entry NP_002005.1 (GeneID 2288).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Immunohistochemistry-Immunofluoresence (IHC-IF)1:50 - 1:500
Documents
Safety Data SheetPDF · IHC-00290Open
Product DatasheetPDF · IHC-00290 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00290 · Lot 1 (current lot)Open
Services
Antibody Conjugation
Antibody and conjugate formats developed together, built to your specification.
Request CustomizationCustom Monoclonal Antibody Discovery Services
Full custom monoclonal development, from immunization through validation.
Explore Monoclonal DevelopmentVHH Discovery
Single-domain antibodies for structurally difficult targets a conventional monoclonal can't reach.
Explore VHH DiscoveryResources
1