Bethyl Laboratories
Rabbit anti-SNUPN Antibody Affinity Purified
Primary
Catalog #A305-567A
TargetSNUPN
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIP
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Product Description
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. Snurportin-1 (SNUPN) interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor [taken from NCBI Entrez Gene (Gene ID: 10073)].
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 310 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetSNUPN
Antigen Species
Human
Gene ID10073
Gene Symbol
SNUPN
Gene Name
snurportin 1
Uniprot IDO95149
Protein Name
Snurportin-1
Alternate Names
Product Information
Applications
IP
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to SNUPN immobilized on solid support.
The epitope recognized by A305-567A maps to a region between residue 310 to 360 of human Snurportin-1 using the numbering given in entry O95149.1 (GeneID 10073).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.
Immunoprecipitation (IP)6 µg/mg lysate
Documents
Product DatasheetPDF · A305-567A · Lot 1 (current lot)Open
Product DatasheetPDF · A305-567A · Lot 1 (current lot)Open
Safety Data SheetPDF · A305-567AOpen
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