Bethyl Laboratories
Goat anti-MCM4 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00038
TargetMCM4
HostGoat
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM4 is part of the core MCM complex that includes MCM4, MCM6, and MCM7. The core complex possesses DNA helicase activity. MCM4 is phosphorylated by CDC2 kinase resulting in a reduction of helicase activity and chromatin binding.
Specifications
Clonality
Polyclonal
Host
Goat
Immunogen
Between 325 and 375
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
500 µg/ml
Target Identity
TargetMCM4
Antigen Species
Human
Gene ID4173
Gene Symbol
MCM4
Gene Name
minichromosome maintenance complex component 4
Uniprot IDP33991
Protein Name
DNA replication licensing factor MCM4
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to MCM4 immobilized on solid support.
The epitope recognized by IHC-00038 maps to a region between residue 325 and 375 of human Minichromosome Maintenance 4 using the numbering given in entry NP_005905.2 (GeneID 4173).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00038Open
Product DatasheetPDF · IHC-00038 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00038 · Lot 1 (current lot)Open
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