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Mouse anti-CIP2A Monoclonal Antibody [2A1-9A4]

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Target:

CIP2A

Reactivity:

Human

,

Mouse

Host:

Mouse

Clonality:

Monoclonal

Clone:

2A1-9A4

Format:

Whole IgG

Immunogen:

Amino terminal one-third of the CIP2A (GeneID 57650) recombinant protein

Isotype:

IgG1-kappa

Conjugate:

Unconjugated

Purity:

Purified

100 µl (10 blots)

20 µl (2 blots)

100 µg (BSA-Free)

Product Details

Specifications
Verified Reactivity

Mouse,

Human

Antigen Species

Human

Concentration
40 µg/ml 1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide


Request Formulation Change

Tris-buffered Saline containing 0.09% Sodium Azide, BSA-Free


Request Formulation Change

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Additional Product Information

CIP2A (cancerous inhibitor of PP2A) was originally identified as p90, a cytoplasmic autoantigen found in the serum from a cancer patient. It was later described as a protein that interacted with the c-myc oncogene and functioned as an inhibitor of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A phosphatase activity by CIP2A prevents c-myc phosphorylation and counteracts c-myc proteolytic degradation, thereby stabilizing c-myc and promoting cell growth and transformation. CIP2A is found to be overexpressed in some human malignancies and is thus classified as an oncogene that may be an important contributor to tumor formation.

57650

CIP2A

cell proliferation regulating inhibitor of protein phosphatase 2A

Q8TCG1

Protein CIP2A

Alternate Names

cancerous inhibitor of PP2A; cancerous inhibitor of protein phosphatase 2A; KIAA1524; p90; p90 autoantigen; protein CIP2A

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots are performed using Goat anti-Mouse IgG Heavy and Light Chain Antibody (Cat. No. A90-216P).