Bethyl Laboratories
Rabbit anti-Abraxas IHC Antibody Affinity Purified
Primary
Catalog #IHC-00630
TargetAbraxas
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
Abraxas was identified in a phosphopeptide affinity proteomic and mass spec analysis as a protein that bound directly to the BRCA1 BRCT repeat. Along with RAP80, Abraxas was required to form a complex with BRCA1 for the DNA damage response.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 359 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetAbraxas
Antigen Species
Human
Gene ID84142
Gene Symbol
ABRAXAS1
Gene Name
abraxas 1, BRCA1 A complex subunit
Uniprot IDQ6UWZ7
Protein Name
BRCA1-A complex subunit Abraxas
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to Abraxas immobilized on solid support.
The epitope recognized by IHC-00630 maps to a region between residue 400 and 409 of human Abraxas (coiled-coil domain containing 98) using the numbering given in entry NP_620775.2 (GeneID 84142).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00630Open
Product DatasheetPDF · IHC-00630 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00630 · Lot 1 (current lot)Open
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