Rabbit anti-Aurora B IHC Antibody Affinity Purified
Product Details
Specifications
The epitope recognized by IHC-00003 maps to a region between residue 300 and the C-terminus (residue 344) of human Aurora B using the numbering given in SwissProt entry Q96GD4 (GeneID 9212). Antibody was affinity purified using an epitope specific to Aurora B immobilized on solid support.
The epitope recognized by IHC-00003-T maps to a region between residue 300 and the C-terminus (residue 344) of human Aurora B using the numbering given in SwissProt entry Q96GD4 (GeneID 9212).
Additional Product Information
Aurora B is the central enzymatic unit of the chromosomal passenger complex (CPC). In the CPC, Aurora B is associated with the passenger proteins inner centromeric protein (INCENP), survivin, and borealin. Aurora B is a serine-threonine protein kinase essential for chromosome segregation and cytokinesis. Specific roles for Aurora B have been demonstrated in cohesin dissociation from centromeres as well as condensin I binding to chromatin.F112. Substrates of Aurora B kinase activity include desmin, septin 1, INCENP, RAC GTPase activating protein 1, and centromeric protein A.
Alternate Names
AIK2; AIM1; AIM-1; ARK2; ARK-2; AurB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora- and Ipl1-like midbody-associated protein 1; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; IPL1; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK-1; STK12; STK5
Applications
Formalin-fixed Paraffin-Embedded Tissue 1:100 - 1:500:
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Formalin-fixed cells 1:100 - 1:500.