Rabbit anti-AXL Recombinant Monoclonal Antibody [BLR222K]
Product Details
Specifications
Immunogen was a recombinant protein representing the extracellular domain of human AXL (aka tyrosine-protein kinase receptor UFO; residues 33-440, NP_068713.2).
Additional Product Information
Axl is a receptor tyrosine kinase (RTK) that binds the ligand Gas6 (growth-arrest specific gene). It is part of a sub-family of RTKs that includes Axl, SKY and MER. The Axl gene was first identified as a transforming cDNA isolated from patients with chronic myelogenous leukemia. Axl-Gas6 signaling is implicated in cellular responses such as cell survival, proliferation, migration, and adhesion, and it may be involved in cancer progression.
Alternate Names
ARK; AXL oncogene; AXL transforming sequence/gene; JTK11; Tyro7; tyrosine-protein kinase receptor UFO; UFO
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.