Bethyl Laboratories
Rabbit anti-BCoR Antibody Affinity Purified
Primary
Catalog #A301-672A
TargetBCoR
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIP
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Product Description
The BCL6 co-repressor (BCOR) was identified in a two-hybrid screen for factors that interact with the POZ domain of BCL6, a transcriptional repressor important to the immune response and B-cell development. BCOR also interacts with class I and II histone deacetylases and has recently been identified in a complexes with polycomb group proteins, RING1, RYBP, SNSC1, and RNF2, and the ubiquitin E3 ligase SKP1, and JHDM1B. Defects in BCOR are associated with oculo-facio-cardio-dental (OFCD) syndrome, a rare X-linked dominant disease that is fatal in males.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 25 and 75
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetBCoR
Antigen Species
Human
Gene ID54880
Gene Symbol
BCOR
Gene Name
BCL6 corepressor
Uniprot IDQ6W2J9
Protein Name
BCL-6 corepressor
Alternate Names
Product Information
Applications
IP
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to BCoR immobilized on solid support.
The epitope recognized by A301-672A maps to a region between residue 25 and 75 of human BCL6 co-repressor using the numbering given in entry EAW59426.1 (GeneID 54880).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.
Immunoprecipitation (IP)6 µg/mg lysate
Documents
Product DatasheetPDF · A301-672A · Lot 2 (current lot)Open
Product DatasheetPDF · A301-672A · Lot 2 (current lot)Open
Safety Data SheetPDF · A301-672AOpen
Citations / Publications
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