Rabbit anti-Bub1 Antibody
Catalog #
Bub1
Human
IHC
,IP
,WB
Rabbit
Polyclonal
Whole IgG
between 1 and 50
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Bub1 is cell cycle checkpoint kinase and component of the spindle checkpoint machinery. Bub1 and other spindle checkpoint proteins ensure that segregation does not proceed until all replicated chromatids are associated with a functional bipolar spindle. Bub1 functions to target Bub1-related protein (BubR1), Mad2, and polo-like kinase to kinetochores. It also functions to phosphorylate Cdc20 and inhibit ubiquitination of Pds1/securin by the anaphase-promoting complex (APC).
Mitotic checkpoint serine/threonine-protein kinase BUB1
Alternate Names
BUB1 budding uninhibited by benzimidazoles 1 homolog; BUB1A; BUB1L; budding uninhibited by benzimidazoles 1 homolog; hBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
Applications