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Rabbit anti-CBX3 IHC Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
CBX3
Reactivity:
Human, Mouse
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 133 and C-term
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (50+ slides)

10 µl (5+ slides)

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Product Details

Specifications
Verified Reactivity
Mouse, Human
Presumed Reactivity
Kenyan clawed frog, Japanese gecko, Sablefish, Pipidae, Atlantic salmon, Medaka fish, Nile tilapia, Duckbill platypus, Green anole, Japanese pufferfish, Zebra finch, Three-spined stickleback, Turkey, White-tufted-ear marmoset, Tasmanian devil, Panda, Monkey, African elephant, Pig, X. laevis, Naked mole rat, Rabbit, Small-eared galago, Chinese hamster, Guinea pig_10141, Little brown bat, Thirteen-lined ground squirrel, Gray short-tailed opossum, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Dog, Bovine, Chicken, Orangutan, Horse, Rat, X. tropicalis
Antigen Species
Human
Stock Concentration
50 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to CBX3 immobilized on solid support.

The epitope recognized by IHC-00204-T maps to a region between residues 133 and the C-terminus (residue 183) of human chromobox homolog 3 using the numbering given in entry NP_009207.2 (GeneID 11335).

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Gene & Protein Information

CBX3 (chromobox protein homolog 3), also known as HP1gamma (heterochromatin protein 1 homolog gamma), is one of 3 isoforms of HP1 that binds heterochromatin and functions as a structural adaptor to stabilize and organize macromolecular complexes with nucleosomes for higher chromatin structure. All of the HP1 isoforms possess a chromodomain and chromoshadow domain and associate with methylated histones that mediate transcriptional repression.

11335

CBX3

chromobox 3

Q13185

Chromobox protein homolog 3

Alternate Names

chromobox homolog 3 (HP1 gamma homolog, Drosophila), chromobox protein homolog 3, HECH, heterochromatin protein 1 homolog gamma, heterochromatin protein HP1 gamma, heterochromatin-like protein 1, HP1 gamma, HP1 gamma homolog, HP1-GAMMA, HP1Hs-gamma, modifier 2 protein

Applications

Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated.

Citations (1)