Bethyl Laboratories
Rabbit anti-CBX3 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00204
TargetCBX3
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
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Product Description
CBX3 (chromobox protein homolog 3), also known as HP1gamma (heterochromatin protein 1 homolog gamma), is one of 3 isoforms of HP1 that binds heterochromatin and functions as a structural adaptor to stabilize and organize macromolecular complexes with nucleosomes for higher chromatin structure. All of the HP1 isoforms possess a chromodomain and chromoshadow domain and associate with methylated histones that mediate transcriptional repression.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 133 and C-terminus
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
50 µg/ml
Target Identity
TargetCBX3
Antigen Species
Human
Gene ID11335
Gene Symbol
CBX3
Gene Name
chromobox 3
Uniprot IDQ13185
Protein Name
Chromobox protein homolog 3
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to CBX3 immobilized on solid support.
The epitope recognized by IHC-00204 maps to a region between residues 133 and the C-terminus (residue 183) of human chromobox homolog 3 using the numbering given in entry NP_009207.2 (GeneID 11335).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00204Open
Product DatasheetPDF · IHC-00204 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00204 · Lot 1 (current lot)Open
Citations / Publications
Services
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Full custom monoclonal development, from immunization through validation.
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Single-domain antibodies for structurally difficult targets a conventional monoclonal can't reach.
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