Rabbit anti-CD146 Antibody Affinity Purified
Catalog #
CD146
Human
,Mouse
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 600 and 650
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Human
2 - 8 °C
1 year from date of receipt
CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. CD146 could be an adhesion molecule active in neural crest cells during embryonic development. CD146 acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P43121].
Alternate Names
CD antigen CD146; CD146; cell surface glycoprotein MUC18; cell surface glycoprotein P1H12; Gicerin; HEMCAM; melanoma adhesion molecule; Melanoma cell adhesion molecule; melanoma-associated antigen A32; melanoma-associated antigen MUC18; MelCAM; METCAM; MUC18; S-endo 1 endothelial-associated antigen
Applications