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Rabbit anti-CEP290 IHC Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
CEP290
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
Between 2429 and 2479
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (50+ slides)

10 µl (5+ slides)

For ordering information, see our International Distributors

Product Details

Specifications
Verified Reactivity
Human
Presumed Reactivity
Monkey, African elephant, Small-eared galago, Gorilla, Northern white-cheeked gibbon, Orangutan, Horse
Antigen Species
Human
Stock Concentration
500 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to CEP290 immobilized on solid support.

The epitope recognized by IHC-00365-T maps to a region between residue 2429 and 2479 of human centrosomal protein 290kDa using the numbering given in entry NP_079390.3 (GeneID 80184).

Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

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Gene & Protein Information

Centrosomal protein 290 (CEP290) is a member of the nephrocystins, a family of proteins involved in renal cystic diseases. CEP290 and the nephrocystins appear to play a role in cilia and basal body function. Loss-of-function mutations in CEP290 result in Joubert syndrome and related disorders characterized by brain malformations, developmental delay, ataxia, irregular breathing, renal disease, and hepatic fibrosis.

80184

CEP290

centrosomal protein 290

O15078

Centrosomal protein of 290 kDa

Alternate Names

3H11Ag, Bardet-Biedl syndrome 14 protein, BBS14, cancer/testis antigen 87, centrosomal protein 290kDa, centrosomal protein of 290 kDa, Cep290, CT87, CTCL tumor antigen se2-2, JBTS5, LCA10, Meckel syndrome, type 4, MKS4, monoclonal antibody 3H11 antigen, Nephrocystin-6, nephrocytsin-6, NPHP6, POC3, POC3 centriolar protein homolog, prostate cancer antigen T21, rd16, SLSN6, tumor antigen se2-2

Applications

Formaldehyde-Fixed Cells 1:100 - 1:500: Permeabilization with Triton-X 100 is recommended. Acetone fixation is not recommended.