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Rabbit anti-CoREST Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
CoREST
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 425 and C-term
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (1000 µg/ml)

100 µl (10 blots)

20 µl (2 blots)

For ordering information, see our International Distributors

Product Details

Specifications
Verified Reactivity
Human
Antigen Species
Human
Stock Concentration
660 µg/ml
1000 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to CoREST immobilized on solid support.

The epitope recognized by A300-130A-T maps to a region between residues 425 and the C-terminus (residue 482) of human REST (RE1-silencing transcription factor) corepressor using the numbering given in entry NP_055971.1 (GeneID 23186).

Immunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

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Gene & Protein Information

CoREST has been identified as a component of a histone deacetylase (HDAC) complex as well as an interacting protein and corepressor of the REST (repressor element 1 silencing transcription factor) transcription factor. HDAC complexes deacetylate chromatin to repress transcription and silence genes. The CoREST complex may be important in restricting gene expression in a tissue-specific manner.

23186

RCOR1

REST corepressor 1

Q9UKL0

REST corepressor 1

Alternate Names

COREST, Protein CoREST, RCOR, REST corepressor 1

Applications

Western blot of lysates performed using standard western blot reagents and 4-20% SDS-PAGE.

Citations (1)