Bethyl Laboratories
Rabbit anti-CSB/ERCC6 Antibody Affinity Purified
Primary
Catalog #A301-347A
TargetCSB/ERCC6
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIP
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Product Description
ERCC6, also known as Cockayne syndrome B protein, is involved in DNA repair in response to UV exposure. ERCC6 has been reported to display ATPase and helicase activity and functions as a transcriptional regulator. Mutations in ERCC6 are the cause of Cockayne syndrome type B (CSB), cerebro-oculo-facio-skeletal syndrome type 1 (COFS1), De Sanctis-Cacchione syndrome (DCS), age-related macular degeneration type 5 (ARMD5), and UV-sensitive syndrome (UVS).
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1175 and 1225
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetCSB/ERCC6
Antigen Species
Human
Gene ID2074
Gene Symbol
ERCC6
Gene Name
ERCC excision repair 6, chromatin remodeling factor
Uniprot IDP0DP91
Protein Name
DNA excision repair protein ERCC-6
Alternate Names
ARMD5 • ATP-dependent helicase ERCC6 • Chimeric CSB-PGBD3 protein • Chimeric ERCC6-PGBD3 protein • CKN2 • Cockayne syndrome group B protein • cockayne syndrome protein CSB • COFS • COFS1 • CSB • CSB-PGBD3 • DNA excision repair protein ERCC-6 • ERCC6-PGBD3 fusion protein • excision repair cross-complementation group 6 • excision repair cross-complementing rodent repair deficiency, complementation group 6 • POF11 • RAD26 • UVSS1
Product Information
Applications
IP
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to CSB/ERCC6 immobilized on solid support.
The epitope recognized by A301-347A maps to a region between residue 1161 and 1211 of human Cockayne syndrome protein B (excision repair cross-complementing rodent repair deficiency, complementation group 6) using the numbering given in entry NP_000115.1 (GeneID 2074).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.
Immunoprecipitation (IP)6 µg/mg lysate
Documents
Product DatasheetPDF · A301-347A · Lot 2 (current lot)Open
Product DatasheetPDF · A301-347A · Lot 2 (current lot)Open
Safety Data SheetPDF · A301-347AOpen
Citations / Publications
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