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Rabbit anti-CSN7b Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
CSN7b
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 225 and C-term
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (1000 µg/ml)

100 µl (10 blots)

20 µl (2 blots)

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Product Details

Specifications
Verified Reactivity
Human
Presumed Reactivity
Bovine, Mouse
Antigen Species
Human
Stock Concentration
100 µg/ml
1000 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to CSN7b immobilized on solid support.

The epitope recognized by A300-044A-T maps to a region between residue 225 and the C-terminus (residue 264) of human constitutive photomorphogenic homolog subunit 7B using the numbering given in TrEMBL entry Q9H9Q2 (GeneID 64708).

Immunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

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Gene & Protein Information

CSN7b is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity.

64708

COPS7B

COP9 signalosome subunit 7B

Q9H9Q2

COP9 signalosome complex subunit 7b

Alternate Names

COP9 constitutive photomorphogenic homolog subunit 7B, COP9 signalosome complex subunit 7b, CSN7B, JAB1-containing signalosome subunit 7b, SGN7b, signalosome subunit 7b

Applications

Western blot of lysates performed using standard western blot reagents and 4-20% SDS-PAGE.