Bethyl Laboratories
Rabbit anti-CSN7b Antibody Affinity Purified
Primary
Catalog #A300-240A
TargetCSN7b
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationWB
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Product Description
CSN7b is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 214 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetCSN7b
Antigen Species
Human
Gene ID64708
Gene Symbol
COPS7B
Gene Name
COP9 signalosome subunit 7B
Uniprot IDQ9H9Q2
Protein Name
COP9 signalosome complex subunit 7b
Product Information
Applications
WB
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to CSN7b immobilized on solid support.
The epitope recognized by A300-240A maps to a region between residue 225 and the C-terminus (residue 264) of human constitutive photomorphogenic homolog subunit 7B using the numbering given in TrEMBL entry Q9H9Q2 (GeneID 64708).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (A120-101P).
Western Blot (WB)1:5000 - 1:25,000
Documents
Product DatasheetPDF · A300-240A · Lot 1 (current lot)Open
Product DatasheetPDF · A300-240A · Lot 1 (current lot)Open
Safety Data SheetPDF · A300-240AOpen
Citations / Publications
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