Bethyl Laboratories
Rabbit anti-EMSY IHC Antibody Affinity Purified
Primary
Catalog #IHC-00416
TargetEMSY
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
Image 1 of 1
local_shipping
Order within 15 hours and 26 minutes for shipment by today
Product Description
EMSY has been identified as a protein that interacts with BRCA2 and suppresses BRCA2 transactivational activity. EMSY is amplified in some cases of sporadic human breast and ovarian cancer indicating a role in tumorigenesis that is linked to BRCA2 function. EMSY can also associate with HP1beta and BS69 and may be involved in chromatin remodeling.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1272 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetEMSY
Antigen Species
Human
Gene ID56946
Gene Symbol
EMSY
Gene Name
EMSY, BRCA2 interacting transcriptional repressor
Uniprot IDQ7Z589
Protein Name
BRCA2-interacting transcriptional repressor EMSY
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to EMSY immobilized on solid support.
The epitope recognized by IHC-00416 maps to a region between residue 1250 and the C-terminus (residue 1322) of human EMSY chromosome 11 open reading frame 30 using the numbering given in TrEMBL entry Q8TE50 (GeneID 56946).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00416Open
Product DatasheetPDF · IHC-00416 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00416 · Lot 1 (current lot)Open
Related Products
Services
Antibody Conjugation
Antibody and conjugate formats developed together, built to your specification.
Request Customization
Custom Monoclonal Antibody Discovery Services
Full custom monoclonal development, from immunization through validation.
Explore Monoclonal Development
VHH Discovery
Single-domain antibodies for structurally difficult targets a conventional monoclonal can't reach.
Explore VHH Discovery
Resources
Standard Western Blot Protocol
Read the Protocol
Immunoprecipitation Protocol
Read the Protocol
Simple Western™ Resources
Explore Simple Western™
1